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李 硕
2012-11-20 10:45 邹金华 

李硕博士

清华大学生命科学院博士;美国国立健康

研究院(NIH)博士后

学术研究包括:

1.水生动物胞外嘌呤能信号分子释放的分子机理。2.水生动物嘌呤能信号通路关键基因的克隆、表达及功能分析。3.嘌呤能信号在水生动物个体发育、渗透适应及疾病防御中的作用。钙结合蛋白的性质及构象与功能的关系。

主要科研成果:

参与了多项863国家高技术发展计划项目、国家自然基金项目及美国国立健康研究院内部科研项目,已累计发表SCI论文20篇(SCI一区文章2篇,二区7篇,三区4篇),累计影响因子超过70,累计它引次数超过200次。其中,第一作者SCI文章6篇(SCI二区1篇,三区3篇,四区2篇),累计影响因子17.965,累计它引次数超过80次。

文章发表(节选):

1. Jindrichova M, Kuzyk P,Li S, Stojilkovic SS, Zemkova H. Conserved ectodomain cysteines are essential for rat P2X7 receptor trafficking.Purinergic Signal. 2012(2012) 8:317–325

2. Shuo Li, Ivana Bjelobaba, Zonghe Yan, Marek Kucka, Melanija Tomic, and Stanko S. Stojilkovic. Expression and roles of pannexins in ATP release in the pituitary gland.Endocrinology. 2011, 152(6):2342–2352.

3. Melanija Tomic, Marek Kucka, Karla Kretshmannova,Shuo Li, Maria Nesterova, Constantine Stratakis, and Stanko Stojilkovic. Role of non-selective cation channels in spontaneous and protein kinase A stimulated calcium signaling in pituitary cells.Am J Physiol Endocrinol Metab, 2011, 301(2):E370-9.

4. Shuo Li, Melanija Tomic, and Stanko S. Stojilkovic. Characterization of novel Pannexin 1 isoforms from rat pituitary cells and their association with ATP-gated P2X channels.General and Comparative and Endocrinology. 2011, 174(2):202-10

5. Yan Z, Khadra A, Li S, Tomic M, Sherman A, Stojilkovic SS. Experimental characterization and mathematical modeling of P2X7 receptor channel gating.The Journal of Neuroscience. 2010, 30(42):14213-24.

6. H. Zemkova, M. Kucka,Shuo Li, A. E. Gonzalez-Iglesias, M. Tomic and S. S. Stojilkovic Characterization of purinergic P2X4 receptor channels expressed in anterior pituitary cells.

Am J Physiol Endocrinol Metab, 2010; 298 (3): E644-E651.

7. Claudio Coddou, Juan F. Codocedo,Shuo Li, Juan G. Lillo, Claudio Acuña-Castillo, Paulina Bull, Stanko S. Stojilkovic and J. Pablo Huidobro-Toro. Reactive oxygen species potentiate the P2X2 receptor channel activity through intracellular Cys430.The Journal of Neuroscience. 2009, 29(39):12284-12291.

8. Zonghe Yan,Shuo Li, Zhaodong Liang, Melanija Tomi , and Stanko S. Stojilkovic. The P2X7 Receptor Channel Pore Dilates under Physiological Ion Conditions.The Journal of General Physiology. 132(2008):563-573.

9. Qin Wang*,Shuo Li*,Changzhong Li, Jian Liang, Zi Fang, Liping Xie and Rongqing Zhang. The extra C-terminal tail is involved in the conformation, stability changes and the N/C-domain interactions of the calmodulin-like protein from pearl oyster Pinctada fucata.Biochimica et Biophysica Acta - Proteins and Proteomics. 1784(2008):1514-1523. (*contributed equally to this work).

10. Shuo Li, Liping Xie, Qingxiong Meng and Rongqing Zhang. Significance of the extra C-terminal tail of CaLP, a novel calmodulin-like protein involved in oyster calcium metabolism.Comparative Biochemistry and Physiology-part B Biochemistry and Molecular Biology.144B(2006): 463-471.

11. Shuo Li, Liping Xie, Zhuojun Ma and Rongqing Zhang. cDNA cloning and characterization of a novel calmodulin-like protein from pearl oyster Pinctada fucata,FEBS J. 272(2005):4899-4910.

12. Shuo Li, Liping Xie, Cen Zhang, Yong Zhang, Mianzhi Gu and Rongqing Zhang. Cloning and expression of a pivotal calcium metabolism regulator: calmodulin involved in shell formation from pearl oyster (Pinctada fucata),Comparative Biochemistry and Physiology-part B Biochemistry and Molecular Biology,138B(2004):235-243.

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