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牛瑞芳教授简介
2020-03-06 10:10  

一、基本信息

姓名: 牛瑞芳;  性别:女;  出生日期: 19651    国籍:中国

工作单位:天津医科大学肿瘤医院肿瘤研究所公共实验室

地址:天津市河西区体院北环湖西路      Email: niuruifang@tjmuch.com

电话:Tel: (86) 022-23340123-6018Lab   手机:18622221365

二、教育经历

2009.9-2012: 天津大学, 生物医学工程专业,博士

1986.9-1989.7: 南开大学, 生物化学专业 硕士

1983.9-1986.7: 南开大学, 生物化学专业 学士

三、研究经历

主要从事乳腺癌发生、发展、转移以及耐药相关分子生物学机制、肿瘤单克隆抗体、基因工程抗体及人源化抗体的研究工作,曾在美国MD Anderson 肿瘤中心做高级访问学者。在乳腺癌耐药和转移的分子机制和相应靶点药物的研究方面取得显著成绩,相关论文发表在 Journal of Proteome Research, Cancer letters, Biomaterials,Biochemical Pharmacology, Journal of Cellular and Molecular Medicine, EuropeanJournal of Pharmaceutics and Biopharmaceutics, Breast Cancer Research andTreatmentMolecular OncologySCI收录杂志上,其中单篇IF大于5以上论文6篇,单篇引用超过50次以上7篇,最高引用136次。研究成果获三项专利授权和天津市科技进步奖多项。

四、学术任职

现为研究员、教授,博士研究生导师。目前担任天津医科大学肿瘤医院肿瘤研究所副所长、公共实验室主任,兼任中华医学会肿瘤分会委员、中国抗癌协会肿瘤标志专业委员会委员,美国AACR癌症研究协会会员,国家自然科学基金和中国博士后基金等项目评审专家,《中国肿瘤临床》执行编委,《中华肿瘤防治杂志》和《现代仪器》编委。

五、近年承担和参与的科研项目:

1.       国家科技部863重点项目“双亲性复合靶向控释纳米药物制剂” (2007AA021802)  

2.       国家科技部863项目“肿瘤蛋白质分子标志物的研究与开发”(2012AA020206

3.       国家自然基金面上项目“TGFβ反式激活EGFR信号通路并促进乳腺癌细胞侵袭转移的分子机制研究”(81772804)

4.       国家自然基金面上项目“P-glycoproteinRack1Src相互作用并促进耐药乳腺癌细胞侵袭转移的分子机制研究” (81472474)  

5.       国家自然科学基金面上项目“Anxa2介导IL-6诱导的SHP2/ErkJAK2/STAT3信号通路激活并促进乳腺癌细胞上皮间质转化的分子机制研究(81372844)”

6.       国家自然基金面上项目“MDR1Anxa2相互作用调节耐药乳腺癌细胞侵袭的分子机制研究” (81071731)  

7.       国家自然基金中以合作项目“针对胰腺癌中VAV1蛋白的研究:机制与治疗手段” (81661148051)  

8.       教育部博士点基金博导类资助课题“Anxa2 介导 IL-6 信号通路并促进乳腺癌细胞上皮间质转化的分子机制研究(20131202110002)”

9.       天津市科委重点项目“Anxa2调控STAT3活性和乳腺癌细胞侵袭的作用机制研究” (12JCZDJC24500)

六、近年发表的代表性论文(标注*为通讯作者):

1.       Zhao Y, Ma J, Fan Y, Wang Z, Tian R, Ji W, Zhang F*, Niu R*. (2018) TGF-β transactivates EGFR andfacilitates breast cancer migration and invasion through canonical Smad3 andERK/Sp1 signaling pathways,  Mol Oncol. 12(3), 305-321.    

2.       Yuan J, Yang Y, Gao Z, Wang Z, Ji W, Song W, Zhang F*, Niu R*. (2017) Tyr23 phosphorylation of Anxa2 enhancesSTAT3 activation and promotes proliferation and invasion of breast cancer cells,  BreastCancer Res Treat. 164(2), 327-340.  

3.       Sun X, Zhang J, Wang Z, Ji W, Tian R, Zhang F*, Niu R*. (2017) Shp2 Plays a Critical Role inIL-6-Induced EMT in Breast Cancer Cells,  Int J Mol Sci. 18(2). pii: E395.    

4.       Yang Y, Wu N, Wang Z, Zhang F, Tian R, Ji W, Ren X, Niu R*. (2016)  Rack1 Mediates the Interaction ofP-Glycoprotein with Anxa2 and Regulates Migration and Invasion ofMultidrug-Resistant Breast Cancer CellsIntJ Mol Sci. 17(10). pii: E1718.  

5.             Zhang F., WangZ., Yuan J., Wei X., Tian R., and Niu R*.(2015) RNAi-mediated silencing of Anxa2 inhibits breast cancer cellproliferation by downregulating cyclin D1 in STAT3-dependent pathway, BreastCancer Res Treat 153, 263-275.

6.             Zhang F., WangZ., Fan Y., Xu Q., Ji W., Tian R., and NiuR*. (2015) Elevated STAT3 Signaling-Mediated Upregulation of MMP-2/9Confers Enhanced Invasion Ability in Multidrug-Resistant Breast Cancer Cells, International journal of molecular sciences16, 24772-24790.

7.             Zhang F., Liu Y.,Wang Z., Sun X., Yuan J., Wang T., Tian R., Ji W., Yu M., Zhao Y., and Niu R*. (2015) A novelAnxa2-interacting protein Ebp1 inhibits cancer proliferation and invasion bysuppressing Anxa2 protein level, Mol CellEndocrinol 411, 75-85.

8.             Yuan J., ZhangF., and Niu R*. (2015) Multipleregulation pathways and pivotal biological functions of STAT3 in cancer, Scientific reports 5, 17663.

9.             Wang T., Yuan J.,Zhang J., Tian R., Ji W., Zhou Y., Yang Y., Song W., Zhang F., and Niu R*. (2015) Anxa2 binds to STAT3 andpromotes epithelial to mesenchymal transition in breast cancer cells, Oncotarget 6, 30975-30992.

10.   Zhang J., Zhang F., and NiuR*. (2015) Functions of Shp2 in cancer, JCell Mol Med 19, 2075-2083.  

11.         Zhang F., ZhangH., Wang Z., Yu M., Tian R., Ji W., Yang Y., and Niu R*. (2014) P-glycoprotein associates with Anxa2 and promotesinvasion in multidrug resistant breast cancer cells, Biochem Pharmacol 87, 292-302.

12.   Zhao P., Wang H., Yu M., Liao Z., Wang X., Zhang F., Ji W.,Wu B., Han J., Zhang H., Wang H., Chang J*., and Niu R*. (2012) Paclitaxel loaded folic acid targeted nanoparticlesof mixed lipid-shell and polymer-core: in vitro and in vivo evaluation, European journal of pharmaceutics andbiopharmaceutics 81, 248-256.

13.   Wu B., Zhang F., Yu M., Zhao P., Ji W., Zhang H., Han J., andNiu R*. (2012) Up-regulation ofAnxa2 gene promotes proliferation and invasion of breast cancer MCF-7 cells, Cell proliferation 45, 189-198.

14.   Han J, Zhang F, Yu M, Zhao P, Ji W, Zhang H, Wu B, Wang Y, Niu R*. (2012) RNA interference-mediated silencing of NANOGreduces cell proliferation and induces G0/G1 cell cycle arrest in breast cancercells. Cancer Lett. 321(1):80-8.  

15.   Niu R, Zhao P, Wang H, Yu M,     Cao S   , Zhang F, Chang J*. (2011) Preparation, characterization, andantitumor activity of paclitaxel-loaded folic acid modified and TAT peptideconjugated PEGylated polymeric liposomesJ Drug Target. 19(5):373-81.  

16.   Zhao P,Wang H,Yu M,Cao S,Zhang F,Chang J*,Niu R*.(2010) Paclitaxel-Loaded,Folic-Acid-Targeted and TAT-Peptide-Conjugated Polymeric Liposomes: In Vitroand In Vivo Evaluation, Pharm Res. 27(9):1914-26.  

17.   Wang H, Zhao P, Su W, Wang S, Liao Z, Niu R*, Chang J. (2010) PLGA/polymeric liposome for targeted drugand gene co-delivery. Biomaterials. 31(33):8741-8.  

18.   Zhang F, Zhang L, Zhang B, Wei X, Yang Y, Qi RZ, Ying G,Zhang N, Niu R*. (2009) Anxa2 plays acritical role in enhanced invasiveness of the Multi-Drug Resistant human breastcancer cells,  J Proteome Res. 8(11):5041-7.  

19.   Yu M, Shi Y, Wei X, Yang Y, Zang F, Niu R*. (2009) MitochondrialDNA depletion promotes impaired oxidative status and adaptive resistance toapoptosis in T47D breast cancer cells,  Eur JCancer Prev.18(6):445–457

20.   Yu M, Yang Y, Shi Y, Wang D, Wei X, Zhang N, Niu R*. (2008) Expression level of BP1mRNA in Chinese breast cancer patients: a potential molecular marker for poorprognosisCancer Science, 99(1):173-178    

21.   Yu M, Shi Y, Zhang F, Zhou Y, Yang Y, Wei X, Zhang L, Niu R*. (2007) Sequence variations of mitochondrialDNA D-loop region are highly frequent events in familial breast cancerJ Biomed Sci. 15(4):535-543.    

22.   Yu M, Zhou Y, Shi Y, Ning L, Yang Y, Wei X, Zhang N, Hao X, Niu R*. (2007) Reduced mitochondrialDNA copy number is correlated with tumor progression and prognosis in Chinesebreast cancer patients. IUBMB Life. 59(7):450-7.  

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