一、个人资料

姓名：李硕

邮箱：skyls@tjnu.edu.cn；办公地点：明理楼A111

招生专业：生物学/水生生物学

二、个人简介

李硕，男，1976年生，博士，研究员，研究生导师。2006年7月毕业于清华大学，获生物学专业生化与分子生物学方向理学博士学位。2006年12月至2011年11月在美国国立健康研究院(National Institutes of Health)从事博士后研究工作，2012年5月通过人才引进进入天津师范大学生命科学学院工作，在The Journal of Neuroscience、Endocrinology、American Journal of Physiology-Endocrinology and Metabolism、Biochimica et Biophysica Acta (BBA) – Biomembranes、Purinergic Signalling、FEBS J、Molecular Immunology、Innate Immunity、Fish & Shellfish Immunology等专业期刊发表SCI 论文 40 余篇（含第一作者一区SCI论文20余篇），累计他引1000 余次。

三、研究方向

研究方向：细胞外核苷（酸）信号在鱼类天然免疫中的作用及相关分子机理。

研究内容：①鱼类胞外ATP信号分子释放的分子机制。②胞外ATP信号对鱼类天然免疫应答的调节作用。③胞外核苷酸受体结构、表达、通道特性及功能研究。④胞外ATP信号在鱼类细胞凋亡中的作用。⑤鱼类胞外ATP天然免疫信号通路的调控机制。

四、科研成果

科研项目：主持国家自然科学基金面上项目、天津市自然科学基金重点项目、天津市高校中青年骨干创新人才推进计划项目各1项，主持完成项天津市自然科学基金、国家留学回国人员科研启动基金、天津市教委高等学校科技发展基金、天津师范大学中青年学术创新计划各1项。

代表性论文：

1. Shuo Li, Xiaoli Chen, Jiafang Li, Xuejing Li, Tianxu Zhang, Gaixiang Hao, Jinsheng Sun*. Extracellular ATP is a potent signaling molecule in the activation of the Japanese flounder (Paralichthys olivaceus) innate immune responses. Innate Immunity. 2020, in press, DOI:10.1177/1753425918804635.

2. Shuo Li, Xiaoli Chen, Nan Wang, Jiafang Li, Yu Feng, Jinsheng Sun*. Identification and characterization of ecto-nucleoside triphosphate diphosphohydrolase 1 (CD39) involved in regulating extracellular ATP-mediated innate immune responses in Japanese flounder (Paralichthys olivaceus). Molecular Immunology. 2019, 112:10-21.

3. Shuo Li, Jiafang Li, Weijiao Peng, Gaixiang Hao, Jinsheng Sun*. Characterization of the responses of the caspase 2, 3, 6 and 8 genes to immune challenges and extracellular ATP stimulation in the Japanese flounder (Paralichthys olivaceus). BMC Veterinary Research. 2019, 15:20.

4. Shuo Li, Ivana Bjelobaba, Stanko S. Stojilkovic*. Interactions of Pannexin1 channels with purinergic and NMDA receptor channels. Biochimica et Biophysica Acta (BBA) – Biomembranes. 2018, 1860(1):166-173

5. Shuo Li, Xiaoli Chen, Gaixiang Hao, Xuyun Geng, Wenbin Zhan, Jinsheng Sun*. Identification and characterization of a novel NOD-like receptor family CARD domain containing 3 gene in response to extracellular ATP stimulation and its role in regulating LPS-induced innate immune response in Japanese flounder (Paralichthys olivaceus) head kidney macrophages. Fish & Shellfish Immunology. 2016, 50:79-90.

6. Shuo Li, Xuejing Li, Xiaoli Chen, Xuyun Geng, Jinsheng Sun*. ATP release channel Pannexin1 is a novel immune response gene in Japanese Flounder Paralichthys olivaceus. Fish & Shellfish Immunology. 2014, 40(1):164-173.

7. Shuo Li, Xuejing Li, Claudio Coddou, Xuyun Geng, Junli Wei, Jinsheng Sun*. Molecular characterization and expression analysis of ATP-gated P2X7 receptor involved in Japanese flounder (Paralichthys olivaceus) innate immune response. PLOS ONE. 2014, 9(5):e96625.

8. Shuo Li, Ivana Bjelobaba, Zonghe Yan, Marek Kucka, Melanija Tomic, Stanko S.     Stojilkovic*. Expression and roles of pannexins in ATP release in the pituitary gland. Endocrinology. 2011, 152(6):2342-2352.

9. Shuo Li*, Melanija Tomic, Stanko S. Stojilkovic. Characterization of novel Pannexin 1 isoforms from rat pituitary cells and their association with ATP-gated P2X channels. General and Comparative Endocrinology. 2011, 174(2):202-210.

10. Shuo Li, Liping Xie, Zhuojun Ma, Rongqing Zhang*. cDNA cloning and characterization of a novel calmodulin-like protein from pearl oyster Pinctada fucata. FEBS J. 2005, 272(19):4899-4910.

五、学术兼职和社会兼职

《Aquaculture》、《Fish & Shellfish Immunology》、《Journal of Fish Diseases》、《Environmental Pollution》、《Frontiers in Physiology》、《Scientific Reports》、《Plos One》、《Comparative Biochemistry & Physiology》、《Medical Science Monitor》等国际期刊审稿人，教育部研究生学位论文评审专家。

六、荣誉称号

2013年荣获天津市第二批“用三年时间引进千名以上高层次人才”称号，2017年荣获“天津市高校中青年骨干创新人才”称号。